ZBP1 Protects Against mtDNA-Induced Myocardial Inflammation in Failing Hearts.
Enzan N, Matsushima S, Ikeda S, Okabe K, Ishikita A, Yamamoto T, Sada M, Miyake R, Tsutsui Y, Nishimura R, Toyohara T, Ikeda Y, Shojima Y, Miyamoto HD, Tadokoro T, Ikeda M, Abe K, Ide T, Kinugawa S, Tsutsui H.
Enzan N, et al.
Circ Res. 2023 Apr 28;132(9):1110-1126. doi: 10.1161/CIRCRESAHA.122.322227. Epub 2023 Mar 28.
Circ Res. 2023.
PMID: 36974722
Free PMC article.
BACKGROUND: Mitochondrial DNA (mtDNA)-induced myocardial inflammation is intimately involved in cardiac remodeling. ZBP1 (Z-DNA binding protein 1) is a pattern recognition receptor positively regulating inflammation in response to mtDNA in inflammatory cells, fibrob …
BACKGROUND: Mitochondrial DNA (mtDNA)-induced myocardial inflammation is intimately involved in cardiac remodeling. ZBP1 (Z-DNA bindi …